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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized by their focus on practical aspects of design which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for a pragmatic trial to be valid and lessen the chance of bias is also essential. A high degree of heterogeneity, however, can cause problems with the trial design.

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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They can also be a great method of determining the causal relationship between an intervention and its results. However, they should not be used to replace explanatory studies.

The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis and 무료 프라그마틱 무료게임 (other) pragmatic trials, which inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study which includes recruitment, design, implementation of the intervention, and follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.